SYNTHESIS OF HEMOGLOBIN

                         HEMOGLOBIN  

     Hemoglobin  is the iron-containing oxygen-transport metalloprotein in the red blood cells (erythrocytes) of almost all vertebrates.

Synthesis of Hemoglobin 

 Basically hemoglobin is a quaternary structure of protein, it is mainly composed of two unit.

 Heme is the prosthetic group and globin is a protein chain which is consist of two alpha and two beta   chain.

                 Heme           +           Globin  

                   (Prosthetic Group)                          (Protein Chain) 

   Synthesis of Globin

Synthesis of Global in occur in cytosol with the help of Two Alpha and too beta chain Two Alpha chain has 2 gene HBA1 & HBA2 at chromosome number 16 and to be changed has HBB gene at chromosome number 11

         

                    Chain                           Gene                         Chromosome 

                 2 alpha                    HBA 1                Number 16

                                                 HBA 2                 Number 16

                 2 beta                      HBB                    Number 11

  Synthesis of Heme 

Hemoglobin Synthesis. Hemoglobin synthesis requires the coordinated production of heme and globin. Heme is the prosthetic group that mediates reversible binding of oxygen by hemoglobin.

Heme is mainly consists of a ferrous ion Fe++ and 4 porphyrin ring inside the mitochondria.

Synthesis of heme occur in mitochondria and cytosol by following stepwise process.

Now synthesis of hemoglobin occur when heme comes from mitochondria and global present in cytosol together bonded and form hemoglobin in cytosol.